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HOW MIGHT YOU DEFY IMAGINATION?

Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission to serve patients drives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Senior Scientist-Protein Mass Spectrometry

Live

What you will do

Lets do this. Lets change the world. In this vital role you will join our growing Biologics Therapeutic Discovery team in Burnaby. Job duties include the implementation of advanced mass spectrometry-based analytical and biophysical techniques for the characterization of reagent and therapeutic protein candidates supporting Amgens early phase discovery programs.

Responsibilities:

This individual will oversee the protein characterization capability at our Burnaby site through daily collaboration with scientists in the Department of Protein Sciences and Antibody Discovery. They will also work closely with team members in South San Francisco and Thousand Oaks.

• Perform intact and sub-unit protein mass analysis with appropriate enzymatic deglycosylation procedures to confirm protein identity supporting a variety of large molecule reagents and candidates.
• Design and execute fit for purpose experiments to identify proteins, PTMs and glycan analysis, disulfide link characterization etc. using peptide mapping capabilities.
• Explore and set up high throughput RPLC-MS/MS based protein foot-printing methods, such as, but not limited to HDX-MS and FPOP.
• Oversee a walk-up protein mass spectrometer system (Open access TOF-MS system) and a UPLC SEC system used for site-wide protein purity measurements.
• Train protein biochemistry staff on best practices in wet and dry lab procedures and assist with mass spectrometry data interpretation where necessary.
• Explore existing and new technologies to aid protein characterization efforts through collaborations with local universities and companies.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dedicated and motivated professional we seek is a scientist with these qualifications.

Basic Qualifications:

Doctorate degree

Or

Masters degree and 4 years of scientific experience

Or

Bachelors degree and 6 years of scientific experience

Preferred Qualifications:

• Expertise in protein characterization through use of intact mass analysis, glycan analysis, bottom up RPLC-MS/MS approaches and other biophysical measurements such as SEC, DSF and SEC MALS/QELLS.
• Expertise in mass spectrometry based epitope mapping techniques such as HDX-MS, FPOP, crosslinking methods etc.
• Experience in proteomics or protein expression or purification
• Experience in Agilent TOFs and Thermo Orbitrap mass spectrometers along with Protein Metrics Inc. software is highly preferred.
• Excellent communication skills (both written and oral), and a consistent track record of academic accomplishments (i.e., peer-reviewed publications and/or patents)
• Ability to work independently in a dynamic environment
• Deep understanding of protein production, post-translational modifications, glycosylation structures etc.

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans and annual company-wide shutdowns
• Flexible work models, including remote work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

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Amgen