Senior Scientist, R&D Proteomics CellCarta, a Contract Research Organization, is seeking a highly motivated Senior Scientist with experience in mass spec-based proteomics to join a collaborative, proteomics focused scientific environment. CellCarta\xe2\x80\x99s leading and proprietary proteomics discovery technologies - ProteoCarta\xe2\x84\xa2 - enables the discovery of novel targets for therapeutics development and the identification of novel protein biomarkers that can significantly reduce risk and enhance clinical development productivity and decision making in pharmaceutical research. Summary Reporting to the Director of R&D, the Senior Scientist\xe2\x80\x99s focus will be on conducting label-free differential quantification and identification of protein biomarkers using the Thermo QExactive as well as conducting MRM-based assays to quantify proteins and their post-translational modifications in various matrices, using the Ab Sciex QTRAP systems. He/she will work independently but closely with proteomics and bioinformatics scientists in a results-driven, collaborative environment. He/she will be responsible for the choice of experimental methodology, carrying out the analyses and providing interpretations and conclusions from the results in a report for each project in a timely fashion. He/she will also advise the scientific team on general biomarker discovery questions, platform design, study design, and data analysis. The Senior Scientist is expected to propose and implement new sample analysis procedures and/or improve existing ones. Responsibilities More specifically, you will participate in the following:

• Perform sample preparation for a variety of biological matrices;
• Perform mass spectrometry analysis and interpret results to ensure validity of conclusions;
• Hands-on experience in operating a variety of electrospray-based LC/MS systems with a high comfort level;
• Responsible for method development both discovery and quantitative method. Ability to also perform method development and validation of PK assay of biomarker(s) and drug products such as biologics/biosimilars;
• Perform in-depth data analysis and interpretation for each experiment;
• Provide clear presentation and summary of analysis results and biological interpretation;
• Design and execute experimental testing;
• Design and execute troubleshooting experiments;
• Propose and implement novel approaches to sample processing and mass spectrometry analysis;
• Train Research Associate to perform new sample preparation or analytical techniques;
• Provide scientific recommendations to improve the quality of results and the platform;
• Monitor data quality and take responsibility for project execution in the laboratory;
• Must be capable of working in a GLP environment.

Education

• M.Sc. or Ph.D in life sciences, chemistry or biochemistry (or equivalent).

Main Requirements

• A minimum of 2 years of relevant experience;
• Prioritize, organize workload and meet deadlines in a fast-paced, changing environment;
• Capable of supervision for specific projects will be an asset;
• May require working in BSL2 environment;
• Solid understanding of mass spectrometry, molecular biology, protein chemistry;
• The candidate must have excellent oral and written communications skills and be able to prepare project reports and make internal and client presentations;
• Excellent interpersonal skills and ability to work collaboratively as part of a fast-paced research team;
• Experience working in industry is a big plus.

Benefits We offer a wide range of benefits including:

• Competitive Wages;
• Vacation and Personal Days;
• Comprehensive Group Insurance Plans;
• RRSP Contribution with Employer Matching;
• Employee Annual Incentive Plan (EAIP);
• Dialogue Telemedicine Service and Employee Assistance Program (EAP);
• OPUS & Cie Contribution;
• Parking Reimbursement;
• Referral Program;
• Career advancement opportunities.

About CellCarta CellCarta is a leading provider of specialized precision medicine laboratory services to the biopharmaceutical industry. Leveraging its integrated analytical platforms in immunology, histopathology, proteomics, and genomics, as well as related specimen collection and logistics services, CellCarta supports the entire drug development cycle, from discovery to late-stage clinical trials. The Company operates globally with facilities located in Canada, USA, Belgium, Australia, and China. Joining CellCarta means working with dedicated professionals who are focused on achieving our mission of impacting the future of patient therapy. We make a difference in the lives of patients around the world! Join us as we make an impact on patient therapy!
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