Job Description

Date Posted: 07/05/2023
Req ID:32526
Faculty/Division: Faculty of Dentistry
Department: Faculty of Dentistry
Campus: St. George (Downtown Toronto)

Description:

About us:

Exciting new advances and global challenges are radically reshaping the field of dentistry. Our vision at the Faculty of Dentistry at the University of Toronto is to not just address and respond to these changes \xe2\x80\x93 but to thoughtfully and conscientiously shape the field of the future.

With our robust and comprehensive educational training programs (DDS, MSc, PhD degrees, IDAPP and other specialty programs), our emphasis on community outreach and care, and our internationally known and interdisciplinary research mission, the Faculty of Dentistry at the University of Toronto continues to earn its reputation as one of the top dental schools in North America. Throughout more than 145 years of dental education -- the oldest, largest and most comprehensive training program in Canada -- we have striven to graduate the highest quality of students while providing the public the highest standards of care.

We are driving by our vision to improve health by advancing dentistry through inspired leadership, innovation, and excellence in education, research and practice.

Your Opportunity:

Professor Michael Glogauer in the Faculty of Dentistry is developing new phosphorylated lantibiotics from oral commensal microorganisms called Streptococcus salivarius. The successful candidate is expected to have significant experience in this field, including developing probiotics from oral streptococci and performing structural analysis on the produced metabolites.

https://www.dentistry.utoronto.ca/faculty-profiles/michael-glogauer

Your Responsibilities Include:

Involved in experimental design to develop phosphorylated lantibiotics into new biotherapeutics; this includes developing new methods for the production/purification of the metabolites, designing new multispecies biofilms models to test for the antibiofilm activity, and developing new immunomodulation assays involving neutrophils, macrophages, and T cells.

Essential Qualifications:

Education \xe2\x80\x93 Ph.D. in Microbiology with 5 years of postdoc experience in salivaricins and lantibiotics.

Experience \xe2\x80\x93 Demonstrated strong experience in lantibiotics and other ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by oral bacteria. Candidate must have strong experience in Whole genome sequencing, multispecies biofilms, comparative genomics, metagenomics, lantibiotics structural biology, and probiotics development. Candidate must have a track record of publishing lantibiotics research in high-impact scientific journals.

Skills \xe2\x80\x93 Microbiology skills, oral bacteria isolation, antagonism tests, peptide extraction, HPLC, UPLC, NMR, Mass spectrometry, Confocal microscopy, Microbiome sequencing, metagenomics analysis, cloning and expression, Flow cytometry.

Other \xe2\x80\x93 Bioinformatics and microbiome sequencing, NMR spectroscopy, and Mass spectrometry.

This opportunity of Research Associate (Limited Term) is a 2-year term appointment, with the possibility of extension.

Closing Date: 07/14/2023,11:59PM ET
Employee Group: Research Associate
Appointment Type: Grant - Term
Schedule: Full-Time
Pay Scale Group & Hiring Zone: R01 -- Research Associates (Limited Term): $47,287 - $88,663
Job Category: Research Administration & Teaching

University of Toronto