Job Description

Company Description
Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, biospecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks\' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Why Work With Us

Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Seattle, WA and Dublin, Ireland. We offer a hybrid work environment with most team members working in-office three days per week.

Key Responsibilities

• Executes experiments as per project objectives, with an emphasis on antibody discovery and functional assessment.
• Carries out complex in vitro experiments using advanced techniques.

• Supports mammalian tissue culture, maintaining numerous tumor cell lines using sterile technique. Works with team to ensure cell lines are properly expanded, cryopreserved, and databases updated as required.
• Qualifies antigen and performs sera titering to support immunization campaigns.
• Performs high throughput antibody characterization using Octet antibody quantification, flow cytometry (cell or bead based), ELISA, and cytotoxicity assays.
• Performs various molecular biology techniques (PCR, cloning, plasmid preparation & purification, etc.) to support antibody discovery platform.
• Performs and optimizes high throughput assays using automation (liquid handlers).
• Performs FACS to interrogate immune repertoires.
• Generates high quality, reproducible data to assist in the selection of lead therapeutic molecules and for elucidation/validation of targets for therapeutic development.
• Analyzes, interprets and presents data.
• Keeps up with ongoing projects through attention to internally generated data.
• May assist in preparation of patent applications, research reports and/or scientific papers.
• Assists in maintaining a clean, organized and operational lab.
• Conducts all activities in accordance with scientific standards, OH&S regulations and established policies and practices.
• Adheres to standard procedures for generating, documenting and archiving data. An accurate, up to date lab notebook or electronic notebook is mandatory.
• Fosters effective and collaborative working relationships with fellow employees and management.

Education and Experience

• BSc with 2-3 years\' related experience or an equivalent combination of education and experience.

Skills and Abilities:

• Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional team. Ability to establish and maintain effective working relationships.
• Good organizational skills and the ability to work effectively in a high paced, fast changing environment while balancing multiple activities. Results-oriented individual.
• Ability to contribute to the development of new methodologies to address scientific questions.
• Critical observation skills and good statistical analysis capability.
• Good oral, presentation, and scientific/technical writing skills.
• MS Office proficiency.
• Good knowledge and experience in performing lab techniques and methods which may include, but not limited to

• cell-based techniques such as tissue culture, cell transfections, flow cytometry and FACS
• high throughput antibody characterization screening
• biochemical and molecular biology techniques, such as ELISA, PCR and cloning
• Good understanding and experience in the use of standard or specialized lab equipment which may include:

• Nucleic acid and protein gel apparatus
• Thermocyclers
• Flow cytometer analyzers and sorters
• Multimode microplate readers
• Fluorescent and/or confocal microscopes
• High content imaging devices
• Octet or Biacore systems
• High-throughput liquid handlers, plate washers, multidrops

Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies.

Our team enjoys:

• Industry leading vacation and paid time off
• Excellent health and wellness benefits
• Zymelife health and wellness benefits
• Paid time off to volunteer in your community
• Matching RRSP / 401K program
• Employee Share Purchase Program
• Employee Equity Program

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.

NOTE TO AGENCIES: Zymeworks values our relationships with our recruiting partners. We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.

Date: Apr 6, 2023

Zymeworks