Job Description

Company Description
Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks\' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

About the Position

We are currently seeking a Co-op Student to join the Antibody Discovery and Engineering group in the Antibody Drug Conjugate (ADC) Therapeutic Development department. The Antibody Discovery and Engineering group is responsible for the discovery of therapeutic antibodies against tumour-associated antigens for the treatment of cancer - encompassing antibody generation, humanization, formatting, and functional characterization - as initial stage on a path towards generating Antibody Drug Conjugate (ADC) therapeutics. The successful candidate will be responsible for supporting experimental tasks related to antibody discovery. The Co-op Student will frequently be challenged to critically analyze results and contribute to the Zymeworks team effort to create best-in-class therapeutics.

This position reports to a Senior Research Associate in Antibody Discovery and Engineering and will be based in our laboratory in Vancouver, BC. The candidate must be available to work on site without relocation assistance.

Key Responsibilities

• Generate engineered cell line models using mammalian gene expression lentiviral vectors and CRISPR-Cas9 technologies.
• Support mammalian tissue culture by maintaining numerous tumor cell lines using sterile technique. Works with team to ensure cell lines are properly expanded, cryopreserved, and databases updated as required.
• Validate engineered models using various techniques such as flow cytometry (cell or bead based), western blotting and Sanger sequencing.
• Performs various molecular biology techniques (PCR, cloning, plasmid preparation & gel electrophoresis, etc.) to support antibody discovery platform.
• May perform FACS to interrogate immune repertoires.
• Performs experiments, interprets, and analyzes data, and prepares and disseminates data presentations for group meetings.
• Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
• Conducts all activities in accordance with scientific standards, OS&H regulations and established Zymeworks policies and practices.
• Contributes to a safe and highly efficient laboratory environment through ordering of consumables, preparation of solutions, stocking of consumables, and maintaining a clean working environment.

Education and Experience

• Currently enrolled in an undergraduate program in Biology, Biochemistry, Immunology or a related discipline and successful completion of at least one relevant co-op term are required.
• Additional experience in cell biology, genomics or oncology would be an asset.
• Availability for an 8-month co-op term is also required.

Skills and Abilities

• Experience involving mammalian tissue culture, FACS, flow cytometry, western blotting, ELISA, high-content analysis, fluorescence imaging, sequencing or basic molecular biology techniques would be an asset.
• Good organizational skills and the ability to work effectively in a high paced, fast changing environment. Results-oriented.
• Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships.
• Excellent oral and written communication skills.
• Good computer skills particularly with Excel and PowerPoint. Experience with or knowledge of GraphPad and FlowJo software considered an asset.
• Basic working knowledge of CRISPR-Cas9 and antibody-drug conjugate structure and function considered an asset.

Why Work for Us?

Innovation. Act with Integrity. Collaboration. Embrace Diversity. Care

We come from many countries, cultures, races, ethnicities, abilities, and nationalities. We bring our passions including singing, biking, swimming, dancing, cooking, volunteering, parenting, coaching, and much more! We are proud of our nearly equal balance of men and women and strengthened by our non-binary and transgender team members. Every employee belongs.

Zymeworks\' employees are passionate, engaged and extremely motivated to succeed. We are excited by the cutting-edge science and technology, the endless possibilities this union holds and the sheer opportunity to be a part of something big. To learn more about Zymeworks Inc., please visit our website at www.zymeworks.com.

How to Apply

If you are interested in this challenging opportunity, please apply via our career page. Please upload your transcript along with your resume and cover letter.

Date: Aug 31, 2023

Zymeworks