Job Description

Company Description
Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks\' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Why Work With Us

Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Seattle, WA and Dublin, Ireland. We offer a hybrid work environment with most team members working in-office three days per week.

Key Responsibilities

• Provides characterization and quantitative analytics expertise to support projects at different stages in the pipeline, from exploratory characterization to in vivo studies.
• Develops, executes and documents intact protein RPLC-MS, native protein LC-MS and peptide mapping analysis to support antibody-drug-conjugate and muti-specific antibody therapeutic development.
• Develops, executes and documents RPLC-MS (MS/MS) quantitative and qualitative analysis of small molecules in different matrices.
• Supports the Analytics team method development efforts through sample and reagent preparation, instrument setup and data collection and analysis.
• Supports antibody/antigen purification by chromatography (Size Exclusion Chromatography, Affinity Chromatography) using AKTA systems.
• Applies analytical skills and judgment in assessing the quality of data and assay performance. Prepares and disseminates data presentations for group/project meetings, summarizes results, and aids in crafting experimental outlines.
• Participates in MS instrument maintenance and calibration.
• Supports the procurement and organization of reagents and chemicals in the Analytics group.
• Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
• Conducts all activities in accordance with scientific standards, OS&H regulations and established Zymeworks\' policies and practices.
• May co-author or author scientific papers.
• Actively works to foster an environment of effective and collaborative working relationships amongst employees, management, and external partners.
• Contributes to a safe and highly efficient laboratory environment.

Education and Experience

• Requires a BSc in chemistry, biochemistry or a similar field with a minimum of 2-3 years\' related experience.
• Embody and champion Zymeworks\' values: Innovate, Act with Integrity, Collaborate, and Care.
• Adhere to the highest professional standards and maintain strict confidentiality on matters that require discretion.
• Must be able to work onsite in Vancouver, BC.

Skills and Abilities

• Good organizational and time management skills and the ability to work effectively in a fast paced, fast changing environment.
• Excellent interpersonal skills with the ability to work effectively and collaboratively as a member of a cross-functional team; ability to establish and maintain effective working relationships.
• Good oral, presentation, and scientific/technical writing skills.
• Knowledge of GraphPad Prism considered an asset.

Advanced knowledge and proficiency in the following techniques

• High performance liquid chromatography.
• Mass spectrometry.
• Protein biochemistry and methods for protein characterization.
• Extraction techniques (protein precipitation, liquid-liquid extraction and SPE).
• Experience with Agilent\xe2\x84\xa2 or Waters \xe2\x84\xa2 HPLC and mass spectrometry instrumentation and software considered an asset.
• General knowledge of antibody and antibody drug conjugate structure/function is an asset.
• Experience with AKTA\xe2\x84\xa2 purification systems is an asset.
• Experience working with biological matrices (plasma, serum) is an asset.
• Experience with Orbitrap\xe2\x84\xa2 mass spectrometry instrumentation is an asset.

Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies.

Our team enjoys:

• Industry leading vacation and paid time off
• Excellent health and wellness benefits
• Zymelife health and wellness benefits
• Paid time off to volunteer in your community
• Matching RRSP / 401K program
• Employee Share Purchase Program
• Employee Equity Program

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.

NOTE TO AGENCIES: Zymeworks values our relationships with our recruiting partners. We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.

Date: Jun 28, 2023

Zymeworks