Job Description

POINT Biopharma is an innovative, high-performance company focused on a hard problem: creating new cancer therapies that are more effective and have fewer side effects than traditional treatments. Our products are targeted radioligands, a technology that hold significant promise to treat cancer. Our company is growing rapidly: we just announced a phase 3 clinical trial for our novel radioligand based prostate cancer treatment, established our U.S. manufacturing center in Indianapolis, and have a pipeline of next generation oncology products in development. We are a creative and agile team accountable to a high standard: to be uniquely better. If you are searching for new and uniquely better career path, you should consider joining the POINT team.

TO BE CONSIDERED, APPLICANTS MUST BE LEGALLY ENTITLED TO WORK IN CANADA.

Location of work

The work location is downtown Toronto near University Avenue and College Street.

Overview

Reporting to the Senior Scientist, Preclinical, the Research Scientist, Preclinical will plan and execute experiments to support early-stage programs and the expansion of POINT\xe2\x80\x99s discovery pipeline. The Research Scientist will also have responsibilities for ordering and managing supply of laboratory consumables and interacting with external vendors to enable an uninterrupted experiment workflow. The ideal candidate will have broad expertise in mammalian tissue culture and cell biology techniques as an approach to generating and validating preclinical tumor models. Furthermore, the ideal candidate will be able to independently design, execute and interpret the results of flow cytometry-based experiments for the purposes of validating target expression. They will work closely with the R&D team at POINT, as well as external partners, to advance candidate radiopharmaceuticals for preclinical development.

Objectives

• Bank and passage BSL level 1/2 cell lines used for in vitro/in vivo experiments.
• Identify and source potential new cell lines that could be used in preclinical tumor models.
• Clone new cell lines using standard gene insertion/stable expression techniques.
• Validate the expression of cloned/overexpressed protein targets in various cell lines.
• Manage inventory, ordering and external vendor interactions for lab supplies and reagents.
• Work discovery and translational R&D scientists to reach go/no-go decision points and meet timelines for key experiments.
• Support collaborative work with external partners through material transfers, validation experiments, etc.

Responsibilities

• Provide lab management support for small scientific team of chemists, biochemists and biologists.
• Produce high-quality data and effectively interpret and communicate experimental results.
• Manage time effectively between multiple projects.
• Meet deadlines for collaborative projects and internal programs.
• Maintain accurate records of experimental details, SOPs, materials on hand, etc.
• Preparation for experiments by planning for reagent use, equipment booking, etc.
• Effective project, inventory and time management
• Interpretation and presentation of experimental results to preclinical teams.
• Maintaining a safe working environment for themselves and others through full compliance with health and safety protocols.

Requirements

• M.Sc. or Ph.D. in biology, biochemistry, or related discipline.
• 5+ years industry experience with M.Sc., 2+ years industry experience with Ph.D.
• Extensive experience with mammalian cell culture, including human and mouse cell lines and primary human/mouse tissue samples.
• Familiarity with aseptic technique and BSL level 1/2 protocols.
• Strong experience with multi-color flow cytometry, and flow cytometry analysis (I.e., FlowJo). Cell sorting experience considered an asset.
• Experience with commercially available assays, such as reporter assays, fluorogenic assays, ELISA, etc.
• Cloning and stable cell line generation by lentiviral transduction, knock-in, or other common techniques.
• Experience interacting with external vendors/suppliers, and ordering and managing reagents
• Knowledge of murine tumor models, including syngeneic models and PDX/CDX.
• Excellent problem-solving and decision-making skills.
• Working knowledge of MS-Office and Graphpad Prism.
• Excellent written and verbal scientific communication skills.
• Knowledge or experience with radiopharmaceuticals is considered an asset but not required.
• This role may require working in collaboration with a hospital setting occasionally, and it is mandatory for all employees to complete health screens before onboarding. In the event the screen results show non-immunity, vaccines may need to be administered.

Why joining POINT today will be the right career move for you:

There is no shortage of demand for smart, qualified and hardworking people like yourself \xe2\x80\x93 and we strongly believe POINT is the right career move for you. Here is why:

• You will help establish and define an organization that will change the course of cancer therapies. and help thousands of people each year
• You will be challenged, and are expected to challenge us, as part of a results-oriented, high performance team, where everyone leaves their egos at the door and lets the best ideas win
• You will be provided the opportunity to participate in the financial value creation that occurs as POINT grows and becomes a mature pharmaceutical company
• Most importantly, you will spend everyday working on something important

If what we are saying resonates with you, please submit a resume.

Benefits

• Eligible for annual incentive bonus plan and stock options
• Healthcare plan (medical, dental, vision) \xe2\x80\x93 effective day 1
• Disability
• Life insurance
• RRSP matching plan

• Paid Time Off (Vacation, Personal Days, Sick Days & Public Holidays)
• $500 fitness reimbursement
• $50 cell phone reimbursement per month ($1,300 per year)

All applicants who are offered employment with POINT Biopharma will be subject to a background investigation. Offers of employment are contingent on the successful completion of a background investigation conducted in accordance with POINT Biopharma policy and state law.

POINT Biopharma does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

We do not accept unsolicited inquiries or resumes from agencies.

POINT Biopharma Global