Job Description

Company DescriptionThe University Health Network, where \xe2\x80\x9cabove all else the needs of patients come first\xe2\x80\x9d, encompasses Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of ground breaking firsts and a purpose of \xe2\x80\x9cTransforming lives and communities through excellence in care, discovery and learning\xe2\x80\x9d, the University Health Network (UHN), Canada\'s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.Union: Non-Union
Site: Princess Margaret Research Institute
Department: Radiation Oncology
Reports to: Principal Investigator
Work Model: On-Site
Hours: 35 hours per week
Salary: $60,000-75,000, annually: To commensurate with experience and consistent with UHN compensation policy
Shifts: Monday - Friday
Status: Temporary Full-Time (2 years contract)
Closing Date: September 16, 2024Position SummaryWe are interested in recruiting a highly dedicated and motivated Postdoctoral Researcher to join the Kwan laboratory at the Princess Margaret Research Institute. We use molecular biology, genomics, cell and mice models to study side effects of cancer treatment, such as breast cancer treatment-related lymphedema. The goal of the research program is to develop novel personalized approaches for the prevention and treatment of long-term side effects of cancer treatment. The successful candidate will perform genomic profiling (e.g., NGS), epigenetic profiling (e.g., MeDIP-seq), bioinformatics analysis, mechanistic gene knockout/overexpression experiments, and drug testing to identify biomarkers and therapeutics for normal tissue toxicity. The candidate will work under the supervision of the Principal Investigator and with established epi/genomic and bioinformatics collaborators.DutiesThe selected applicant will have the opportunity to contribute to several projects including: * Evaluation of circulating biomarkers (e.g., cell-free DNA) of normal tissue toxicity related to cancer treatment

• Investigating the mechanisms of action underlying side effects related to cancer treatment

Duties are listed below:

• Perform genomic profiling (e.g., NGS), epigenetic profiling (e.g., MeDIP-seq), and bioinformatics analysis
• Perform genetic knockout/overexpression experiments of candidate genes in cell and mice models
• Perform drug evaluation in cell and mice models
• Mice handling and microsurgery
• Write and publish peer-reviewed scientific publications

Professional and Career DevelopmentIn addition to scientific knowledge and skill development, the selected applicant will have access to unique educational and networking opportunities. Examples are below:

• Enrolment with the UHN Office of Research Trainees (ORT) for complementary training and professional development
• Access to the UHN Princess Margaret Research Institute\'s scientific seminars and rounds
• Access to training programs including the Princess Margaret Cancer Centre\'s Biosciences Oncology Leadership Development (BOLD) Program
• Mentorship in manuscript writing and review, grant writing, and supervision of trainees
• Conference travel

Qualifications

• Candidates must have at minimum a PhD in Molecular Biology or relevant field of study
• At least 3 years of experience with nucleic acid isolation, quantitative real-time PCR, ELISAs, western blotting, immunohistochemistry, immunofluorescence, cell culture, lentiviral transduction, CRISPR gene editing, genomic sequencing, epigenetic profiling, flow cytometry, and mouse handling
• Experience with Incucyte, X-RAD 225Cx, Fluorescence Microscopy, and/or GraphPad are assets
• Willingness to learn new techniques and technologies
• Ability to plan experiments and analyze data

Additional InformationInterested applicants should submit their CV (including a list of first-authored publications), contact information of three referees (including current/former supervisors), and a statement of research interest to Dr. Kwan ( ).Applications will be reviewed on a rolling basis until the position is filled.In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP

) * Close access to Transit and UHN shuttle service

• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN\'s attendance management program, to be eligible for consideration.All applications must be submitted before the posting close date.UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.We thank all applicants for their interest, however, only those selected for further consideration will be contacted.

University Health Network