Job Description

Research Scientist

About Us:

Eupraxia is a clinical-stage biotechnology company focused on developing locally delivered, extended-release products that have the potential to address therapeutic areas with high unmet medical need. DiffuSphere(TM), a proprietary, polymer-based micro-sphere technology, is designed to facilitate targeted drug delivery of both existing and novel drugs. The technology is designed to support an extended duration of effect and delivery of drugs in a hyper-localized fashion, targeting only the tissues that physicians want to treat. We believe the potential for fewer adverse events may be achieved through the precision targeting and the stable and flat delivery of the active ingredient when using the DiffuSphere(TM) technology, versus the peaks and troughs seen with more traditional drug delivery methods. The precision of Eupraxia's DiffuSphere(TM) technology platform has the potential to augment and transform existing FDA-approved drugs to improve their safety, tolerability, efficacy and duration of effect. The potential uses in therapeutic areas may go beyond pain and inflammatory gastrointestinal disease, where Eupraxia currently is developing advanced treatments, also to be applicable in oncology, infectious disease and other critical disease areas.





Eupraxia's EP-104GI is currently in a Phase 1b/2a trial, the RESOLVE trial, for the treatment of EoE. EP-104GI is administered as an injection into the esophageal wall, providing local delivery of drug. This is a unique treatment approach for EoE. Eupraxia also recently completed a Phase 2b clinical trial (SPRINGBOARD) of EP-104IAR for the treatment of pain due to knee osteoarthritis. The trial met its primary endpoint and three of the four secondary endpoints. In addition, Eupraxia is developing a pipeline of later and earlier-stage long-acting formulations. Potential pipeline indications include candidates for other inflammatory joint indications and oncology, each designed to improve on the activity and tolerability of currently approved drugs. For further details about Eupraxia, please visit the Company's website at: www.eupraxiapharma.com.





We are looking for someone who would like to work for a fast-paced, growing company that fosters a creative spirit and integrated teamwork and who is eligible to work in Canada, onsite in Vancouver, BC.

:

Eupraxia is seeking a Research Scientist to contribute to the R&D of pipeline products and the existing lead drug candidate for the treatment of osteoarthritis and eosinophilic esophagitis. The successful candidate will be a highly motivated, independent and creative scientist ideally with previous academic and/or industrial experience working with extended-release technologies. This position requires someone who can work both independently and in a team environment and has excellent communication skills, attention to detail and organizational skills.

Reports to:

Associate Director, Pharmaceutical Development

Responsibilities:

Conduct R&D scale experiments at our Laboratory site to explore new pipeline ideas and support our existing products. Interpret experimental results and present findings in a clear and concise manner at regular team meetings and via written reports. Develop relevant analytical methods as needed. Perform scientific literature searches and use findings to inform experimental work. Develop and maintain our laboratory capabilities, performing other laboratory duties as needed. Assist in the day-to-day supervision of co-op students as needed. Contribute to appropriate sections of regulatory filings including an IND or IMPD. Comply with required Quality Management System procedures including maintenance of a laboratory notebook.

Requirements:

A PhD in a scientific field (e.g., chemistry, biochemistry, pharmaceutical sciences, or a related discipline, OR and MSc with 4 years of relevant academic or industrial experience. Proven experience in designing and conducting experiments related to material synthesis and characterization. Experience with a broad range of analytical and characterisation techniques (e.g., NMR, mass spectrometry, HPLC, GPC). Excellent written and verbal communication skills. Strong interpersonal skills to effectively collaborate with the science team and manage R&D programs in a flexible, small company environment. A life-long learner mindset and a critical thinker, committed to continuous growth and problem-solving.

Additional attributes:

Highly motivated self-starter. Able to work independently and as part of a study team. Detailed oriented with a view to the overall scope of the project. Organized. Accountability. Self-directed learner. Familiarity with processes including fluid-bed coating, spray drying and granulation is an asset. Knowledge of polymer composition, metabolic pathways and structural analysis is advantageous.

Salary Range:

CAD$70,000-100,000 annually



Within the posted range, individual pay is determined by job-related skills, relevant experience, education and/or training. Please note that the range details above reflect the base pay only. A bonus will be available based on performance and remaining in post for the agreed contract duration. We also have a competitive benefits package on offer.





This is an opportunity to work in a small, entrepreneurial, and highly motivating environment, with a strong emphasis on work/life balance and a supportive company culture.





While only short-listed candidates will be notified, we thank each applicant for their submission.