Job Description

We come from many countries, cultures, races, ethnicities, abilities and nationalities. We bring our passions including singing, biking, swimming, dancing, cooking, volunteering, parenting, coaching and much more! We are proud of our nearly equal balance of men and women and strengthened by our non-binary and transgender team members. Every employee belongs.

We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Company Description

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

spectrometry to join the Analytics group within the ADC Therapeutic Development department. The Analytics group is responsible for biophysical characterization of antibodies, antibody drug conjugates (ADCs) and/or other therapeutic proteins, and the advancement of ADC therapeutic candidates and platform technologies. The successful candidate will be part of a dynamic and motivated team responsible for supporting pipeline program advancement and contributing to core platform technology improvements and innovation. The candidate will be challenged to critically analyze results and contribute to the Zymeworks team effort to create clinically and commercially relevant therapeutics.

This position will report to our Associate Scientist, Mass Spectrometry and will be based in our laboratory in Vancouver, BC

As a condition of employment, Zymeworks requires all employees to be fully vaccinated against Covid-19 and provide verification of such. To be considered fully vaccinated, all 3 doses are required.

Key Responsibilities

• Provides characterization and quantitative analytics expertise to support projects at different stages in the pipeline, from exploratory characterization to in vivo studies.
• Develops, executes and documents intact protein RPLC-MS, native protein LC-MS and peptide mapping analysis to support antibody-drug-conjugate and multi-specific antibody therapeutic development.
• Develops, executes and documents RPLC-MS (MS/MS) quantitative and qualitative analysis of small molecules in different matrices.
• Supports the Analytics team method development efforts through sample and reagent preparation, instrument setup and data collection and analysis.
• Supports antibody/antigen purification by chromatography (Size Exclusion Chromatography, Affinity Chromatography) using AKTA systems.
• Applies analytical skills and judgment in assessing the quality of data and assay performance. Prepares and disseminates data presentations for group/project meetings, summarizes results, and aids in crafting experimental outlines.
• Participates in MS instrument maintenance and calibration.
• Supports the procurement and organization of reagents and chemicals in the Analytics group.
• Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
• Conducts all activities in accordance with scientific standards, OS&H regulations and established Zymeworks' policies and practices.
• May co-author or author scientific papers.
• Actively works to foster an environment of effective and collaborative working relationships amongst employees, management, and external partners.
• Contributes to a safe and highly efficient laboratory environment.

Qualifications and Education

• Requires a BSc in chemistry, biochemistry or a similar field with a minimum of 2-5 years' related experience.
• Must be able to work onsite in Vancouver, BC.

Skills and Abilities

• Good organizational and time management skills and the ability to work effectively in a fast paced, fast changing environment.
• Excellent interpersonal skills with the ability to work effectively and collaboratively as a member of a cross-functional team; ability to establish and maintain effective working relationships.
• Good oral, presentation, and scientific/technical writing skills.
• Knowledge of GraphPad Prism considered an asset.
• Advanced knowledge and proficiency in the following techniques
• High performance liquid chromatography.
• Mass spectrometry.
• Protein biochemistry and methods for protein characterization.
• Extraction techniques (protein precipitation, liquid-liquid extraction and SPE).
• Experience with Agilent or Waters HPLC and mass spectrometry instrumentation and software considered an asset.
• General knowledge of antibody and antibody drug conjugate structure/function is an asset.
• Experience with AKTA purification systems is an asset.

NOTE TO EMPLOYMENT AGENCIES: Zymeworks values our relationships with our Recruitment Partners. We will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.