Job Description

Company Overview

Solid State Pharma Inc. (SSPI) is a leading pharmaceutical research organization specializing in preformulation and crystallization engineering. We provide end?to?end expertise in solid?state development, including polymorph, salt, and co?crystal screening, as well as crystallization process design, optimization, and scale?up.

Our success is built on a unique integration of crystallization fundamentals, deep solid?form science, and years of hands?on experience supported by advanced high?throughput methodologies. This combination allows us to deliver fast, reliable, and scientifically rigorous solutions to complex solid?state challenges.

SSPI's research capabilities span a wide range of critical development areas, including: pharmaceutical crystallization engineering, polymorph, salt, and co?crystal screening, preformulation, chiral resolution, polymorph quantification, conversion of amorphous materials to crystalline solids, chemical and crystallization process modeling, size reduction and milling and solid state analytical services.

We partner with pharmaceutical companies around the world to help them fully understand and control the solid?state landscape of their drug candidates, providing toxicology?enabling formulation support that leads to more robust development pathways and improved product performance.

Summary

The "Preformulation Scientist" position is a key contributor to the ongoing research at SSPI. The "Preformulation Scientist" will support early-stage drug development, with a strong focus on toxicology-enabling formulations, excipient compatibility, and solid-state informed formulation design. It is expected to have 70% lab work.

Job Responsibility

Design and develop toxicology-enabling formulations for in vivo preclinical studies (rodent and non-rodent), including: solutions, suspensions, emulsions, and lipid-based formulations.

Select formulation approaches based on API physicochemical properties, exposure targets, and route of administration. Design and execute excipient compatibility studies, including lipid-API interactions.
Assess chemical and physical stability under short-term and accelerated conditions appropriate for tox studies.

Design and preform high throughput screening, solubility measurements and characterization.

Characterize the generated samples using X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermal Gravimetry Analysis (TGA), Liquid Nuclear Magnetic Resonance (NMR), Dynamic Vapor Sorption (DVS), Optical Microscope, Scanning Electron Microscope (SEM), Particle Size Analyzer and HPLC.

Interpret thermal, spectroscopic, and chromatographic data to guide excipient and formulation selection.

Integrate solid-state data (polymorphs, salts, amorphous forms) into formulation decisions.

Record all details of experiments and analytical data

Write high quality weekly and final reports

Routinely present the project results

Follow the safety rules and housekeeping principles to ensure all working areas are clean and safe

Other responsibilities as assigned

Education & Experience

PhD or MSc, in pharmaceutical sciences, chemistry, chemical engineering, physics, or related field. Minimum 5 years of hands-on experience in preformulation and early formulation development. Demonstrated experience with tox-enabling formulations, including lipid-based systems.

Job Type: Full-time

Benefits:

Company events Dental care Disability insurance Extended health care Life insurance Paid time off RRSP match Tuition reimbursement Vision care
Work Location: In person