Job Description

Company Description
Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks\' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.Why Work With UsNothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, Singapore and the Bay Area.Work RequirementThis role is full-time onsite, based out of our Vancouver laboratory, as well as our Vivarium located at UBC.Key Responsibilities

• Applies preclinical in vivo mouse pharmacology models to enable translation of cancer therapies.
• Handles mice (awake and/or under gaseous anesthetic, or after euthanasia) including subcutaneous, intraperitoneal and intravenous injections, frequent tumor/bodyweight measurements, blood and tissue collection.
• Performs regular health monitoring and routine care of mice.
• Prepares drugs using sterile BSL procedures for administration to mice.
• Thaws, prepares, and injects human immune cells via intravenous injection into mice.
• Performs mouse study-related administrative tasks including regulatory documentation and inputting scientific data records.
• Coordinates ex-vivo sample management including sample receipt/collection, organization, and archiving. Maintains complete and accurate records throughout the process.
• Maintains high levels of productivity, organization, and teamwork in the laboratory, including the use of inventory management systems.
• Documents detailed observations, variances methods, raw and analyzed data and results.
• Maintains workspace (laboratory and animal facility rooms) and performs routine duties to keep areas stocked, clean, neat and in efficient operational order.
• Updates lab and vivarium inventory, orders reagents as needed.
• Effectively organizes and schedules activities in the animal facility and/or laboratory with teammates.
• Conducts all activities in accordance with scientific standards, Canadian Council on Animal Care (CCAC) and OH&S regulations and established policies and practices.
• Fosters effective and collaborative working relationships with fellow employees and management.
• Mammalian tissue culture, including maintaining multiple tumor cell lines using sterile technique, and expanding, cryopreserving, and thawing cell lines.
• Support routine analysis of biological samples using ELISA and MSD assays as needed.
• Collect, document and process blood samples for downstream analysis.
• Assist with isolation and culture of lymphocyte populations from mouse organs for pharmacodynamic analysis as needed.
• Helps prepare basic written reports of experiments. Consults with others for data interpretation. Communicates results to working group.

Education and Experience

• BSc in a scientific discipline or Veterinary Technician Diploma and hands-on experience in mouse husbandry and veterinary techniques.

Skills and Abilities:

• Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional team. Ability to establish and maintain effective working relationships.
• Good organizational skills and the ability to work effectively in a high paced, fast changing environment. Results-oriented.
• Working knowledge of regulations, standards and guidelines for care and use of vertebrate animals in research (CCAC guidelines) and animal care protocols.
• Commitment to performing work with the highest regard for animal welfare.
• Consistent and diligent attention to detail and excellent record keeping skills.
• Dedicated work ethic and flexibility to work full-time alone and/or in a small team in an animal facility.
• Proven track record of working with and direct handling of small animal models (rodents) and performing procedures associated with test article administration and sample collection is preferred.
• Ability to consistently perform tail vein injections to produce reproducible results is beneficial
• Experience with mouse tumor models, including xenografts, in vitro cell culture techniques and/or immunological assays and syngeneic model experience is an advantage.
• Embody and champion Zymeworks\' values: Act with Integrity. Collaborate. Care.
• Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion.

Total RewardsWe offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies.The Canadian base salary range for this full time position is $48,000 - $74,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location.The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all Canadian locations. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate\'s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).Please note that the compensation details listed in role postings reflect the base salary only, and do not include bonus, equity, or benefits.Our team enjoys:

• Industry leading vacation and paid time off
• Excellent health and wellness benefits
• Zymelife health and wellness benefits
• Paid time off to volunteer in your community
• Matching country specific pension savings program
• Employee Share Purchase Program
• Employee Equity Program

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.NOTE TO AGENCIES: Zymeworks values our relationships with our recruiting partners. We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.Date: Jul 31, 2024

Zymeworks