Job Description

Career Category Scientific

Join Amgen's Mission of Serving Patients
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission--to serve patients living with serious illnesses--drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Scientist - Target Discovery & Validation - Induced Proximity Platform (IPP)
What you will do
Let's do this. Let's change the world. Amgen is seeking a passionate and innovative Scientist to join the Induced Proximity Platform team in Burnaby. This role is at the frontier of discovery biology, combining induced proximity technologies to uncover novel therapeutic targets across Amgen's key therapeutic areas including Oncology, Inflammation, and Cardiometabolic diseases.
The successful candidate will bring expertise in cell surface target identification and validation, as well as target functionalization toward development of multispecific medicines for all therapeutic areas. You will play a key role in driving innovation, developing technologies, and integrating multi-omics approaches to advance Amgen's discovery pipeline.

• Design, implement, and execute complex experimental workflows to profile and validate cell surface proteins.
• Lead and support cell surface-based target discovery and validation projects using in vitro models (cell lines, primary cells, tissues, etc.).
• Develop approaches to validate proximity at the membrane using techniques including proximity ligation assays (PLA), Alphascreen/AlphaLISA and co-immunoprecipitation assays.
• Develop high throughput copy number analysis and receptor quantification assays using flow cytometry.
• Apply proximity labeling, cell surface enrichment, and related proteomics efforts for target validation and nomination studies.
• Support target validation using tag-based approaches and cell line engineering.
• Support target functionalization efforts toward developing multispecific antibody therapeutics, and perform efficacy, mechanism of action (MoA) and drug response studies for these therapeutics.
• Use cutting-edge software tools and collaborate with bioinformatics to analyze and interpret target discovery proteomics datasets.
• Collaborate across multidisciplinary teams to drive integrated target discovery, validation and functionalization efforts.
• Present findings internally and externally through team meetings, conferences, and peer-reviewed publications.
• Maintain detailed electronic lab notebooks and experimental records.

What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Scientist with these qualifications.
Basic Qualifications:

• Doctorate degree or
• Master's degree and 2 years of relevant scientific experience or
• Bachelor's degree and 4 years of relevant scientific experience

Preferred Qualifications:

• Expertise in flow cytometry is a must.
• Expertise in proximity labeling proteomics platforms and target validation using flow cytometry, biochemical and imaging-based techniques.
• Expertise in cellular proximity-based assays like PLA and Alphascreen/AlphaLISA technology.
• Experience in cell line generation and overexpression systems (e.g., lentiviral delivery).
• Experience with antibody therapeutics and functional validation of targets using cell-based assays.
• Familiarity with high-throughput automation platforms (e.g., Agilent Bravo), high-content imaging platforms and analysis software.
• Track record of scientific innovation, publications, and/or conference presentations.
• Demonstrated ability to work collaboratively in fast-paced, multidisciplinary teams.
• Excellent verbal, written, and organizational skills.

What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The salary range for this position is $110,717 - $140,299 CAD.
Amgen is proud to have been recognized as one of LinkedIn Top 25 Companies in Canada for career growth. Click for more details.
In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
Apply now and make a lasting impact with the Amgen team.
careers.amgen.com
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
.

Skills Required