Job Description

Company Description
UHN is Canada's #1 hospital and the world's #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.
UHN's vision is to build A Healthier World and it's only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

Union: Non-Union
Number of vacancies: 1
Site: MaRS Centre, 101 College Street, Princess Margaret Research Tower, Toronto, Ontario, Canada, M5G 1L7
Department: Research
Reports to: Dr. Trevor Pugh, Dr. Suzanne Trudel
Hours: 37.5 hours per week
Shifts: Day
Status: Temporary Full-time
Closing Date: August 15, 2025
Position Summary
A postdoctoral fellowship is available in the laboratories of Dr. Trevor Pugh, PhD, FACMG and Dr. Suzanne Trudel MD at the Princess Margaret Cancer Centre / University Health Network in Toronto, Canada. Located in the MaRS Centre in the heart of the downtown Discovery District, we are an integral component of multiple translational genomics projects and platforms including the , , . This position will support fellows wishing to lead the collaborative, clinically-oriented myeloma genome analysis projects.
This position is an opportunity for scientifically creative, computationally-inclined individuals with a strong cancer biology background to join our team focused on developing blood-based precision medicine approaches for Multiple Myeloma (MM). This project leverages whole-genome sequencing (WGS) of cell-free DNA (cfDNA) to enable non-invasive detection, molecular characterization, and longitudinal monitoring of MM. The successful candidate will lead efforts in integrating cfDNA WGS data with clinical and bone marrow biopsy data, with the goal of reconstructing the MM genome, identifying actionable mutations, and developing novel biomarkers for minimal residual disease (MRD) and treatment resistance. This position offers the opportunity to work with cutting-edge sequencing technologies, including 200X cfWGS, and innovative computational tools in a translational research environment.
Candidates must have a PhD or MD with specialization in genetics, molecular biology, bioinformatics, or computer science as well as hands-on experience in the use of Unix/Linux, R/Matlab, and statistical approaches to analyze and visualize genome-scale data sets. Preferred but not required are expertise in Python and Java programming, web and database development, industry software development practices (version control, etc.), and expertise using tools for analyzing next-generation sequencing data such as the Genome Analysis Toolkit, the Picard suite of tools, and mutation detection algorithms. Candidates must be highly motivated, possess excellent organizational, problem-solving and communication skills (both verbal and written), and should have prior publications in cancer, genomics, immunology, and/or biomedical journals.
Applicants should apply with a curriculum vitae and a cover letter in PDF format describing specific disease areas of interest to you, how your past experience may complement training in computational cancer genomics, and your future career goals. Applicants will be expected to apply for UHN's initiative to support this opportunity. A link to an active github repository showing past work would be viewed favourably.
Duties

• Will lead efforts in integrating cfDNA WGS data with clinical and bone marrow biopsy data, with the goal of reconstructing the MM genome, identifying actionable mutations, and developing novel biomarkers for minimal residual disease (MRD) and treatment resistance.
• Work with cutting-edge sequencing technologies, including 200X cfWGS, and innovative computational tools in a translational research environment.

Qualifications

• Ph.D. must be obtained within the previous 5 years in a related field
• Background in oncology/immunology, genomics, bioinformatics
• Experience in WGS, WGTS, scRNASeq data analysis
• Experience in Python, Linux, R and MatLab
• Applies fundamental knowledge of research principles, theories, and concepts
• Contributes to the development of new principles and concepts
• Keeps abreast of scientific developments

Additional Information
Why join UHN?
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP

) * Close access to Transit and UHN shuttle service

• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.
All applications must be submitted before the posting close date.
UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.
Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.
UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.
We thank all applicants for their interest, however, only those selected for further consideration will be contacted.