Job Description

INTERNAL APPLICATIONS ONLYAbout OICROICR is Ontarioxe2x80x99s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the biggest challenges in cancer research and deliver real-world solutions to find cancer earlier and treat it more effectively. We are committed to helping people living with cancer, as well as future generations, live longer and healthier lives.Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.Job DetailsPosition: Postdoctoral FellowLocation: MaRS Centre, TorontoDepartment: Computational Biology (Stein Lab)Reports To: Acting Scientific Director and Head, Adaptive OncologySalary: Commensurate with level of experienceHours: 35 hours/weekJob Type: HybridStatus: Full-time, Temporary (1 year)Position SummaryThe Ontario Institute for Cancer Research (OICR) is seeking a Postdoctoral Fellow to develop algorithms capable of generating realistic synthetic cancer genomes for use in benchmarking and training. We seek a PhD with strong computational and data management skills, as well as experience in multi-PI collaborative projects. The fellow will work under the co-supervision of Drs. Lincoln Stein and Bo Wang (UHN, Vector) to design and train a series of generative artificial intelligence (AI) applications to simulate the patterns of mutations observed in cancer genomes. In addition, the fellow will participate in other cancer genome-related machine learning and AI projects as opportunities arise.This position is temporary, full-time for one-year.Position Responsibilities

• Develop and test frameworks for generating somatic mutations with the same characteristics and frequency distributions as those observed in specific tumour types.
• Evaluate the generated genomes for fidelity and iteratively improve the framework.
• Publish the genome generator algorithms in a peer-reviewed journal.
• Work with the laboratory's collaborators to incorporate the generator into tools that simulate short- and long-read sequencing in order to generate a simulated set of cancer genome sequencing reads.
• Release the generator algorithm as an open source package.
• Publish a repository of synthetic genomes with known ground truth.
• Participate in single cell sequencing journal club and laboratory group meetings.
• Work with supervisor to develop a personalized program designed to provide appropriate training in student mentorship, the design and ethical conduct of human studies, laboratory management and budgeting, and research grant preparation

Qualifications

• A recent PHD in computational biology, bioinformatics, or related fields
• Experience with sequence and/or genome analysis
• Self-motivated individual eager to learn new techniques in computational biology and bioinformatics
• Expert with modern machine learning and generative AI tools, such as PyTorch
• Strong familiarity with Git source code control system and software engineering best practices
• Excellent communication skills

For more information about OICR, please visit the website at .To learn more about working at OICR, visit our .POSTED DATE: December 20, 2024
CLOSING DATE: January 3, 2025 at 12:00 p.m.OICR is committed to fostering a climate of equity, diversity, inclusion, and accessibility. This commitment is central to, and mutually supportive of, our research excellence mandate. We welcome and respect the diversity of all members of our community and we support an inclusive culture for all. We welcome all applicants, and encourage applications from racialized persons, Indigenous Peoples, women, persons with disabilities, LGBTQ2S persons, and others who may contribute to furthering a diversity of ideas within our community. OICR is committed to fair assessment of a candidatexe2x80x99s abilities, and consideration for diversity of thought, method, and experience. Providing an accessible workplace and recruitment process is important to us, as described in our Accessibility Plan ( ). Should you require accommodation during any stage in the recruitment process, please complete the form at the bottom of page . Information received related to accommodation will be handled confidentially.Resume Format: If you elect to apply, please click on the xe2x80x9cApply for this Jobxe2x80x9d button below. You will be required to enter contact details, and to attach your resume to your application. Please attach your resume as a .pdf or .doc file.The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.

Ontario Institute for Cancer Research