Job Description

Position: Postdoctoral Fellow
Location: MaRS Centre, Toronto
Department: Drug Discovery Program
Reports To: Senior Scientific Advisor
Salary: Commensurate with level of experience
Hours: 35 hours/week
Job Type: Onsite
Status: Full-Time, Temporary (2-year contract with potential for renewal)

The Ontario Institute for Cancer Research (OICR) is seeking a talented post-doctoral fellow to participate in projects with the aim of discovery of potent small molecule modulators of drug target function towards development of therapeutics for various cancers. These projects include characterization of drug targets, their function, assay development, small molecule screening, and other related in vitro drug discovery processes in Prof. Masoud Vedadi\xe2\x80\x99s lab at OICR in a collaborative environment ( ). The target proteins include protein complexes and protein-protein interactions, protein degradation, and DNA repair pathways. A few examples of the most recent publications from Vedadi\xe2\x80\x99s lab are: PMIDs:36948210, 37749144, 38104184.

This position is temporary, full-time for two-years, with the possibility of renewal.

OICR is Ontario\xe2\x80\x99s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the biggest challenges in cancer research and deliver real-world solutions to find cancer earlier and treat it more effectively. We are committed to helping people living with cancer, as well as future generations, live longer and healthier lives.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.

Position responsibilities include:

• Perform biophysical and biochemical characterization of cancer drug targets.
• Develop and optimize assays for high-throughput screening.
• Employ various screening methods towards discovery of small molecule modulators of the function of the drug targets.
• Work within a teamwork environment towards potent, selective and cell active small molecules for drug discovery.
• Maintain meticulous records of experimental procedures and data.
• Liaise effectively with multi-disciplinary team members (computational chemistry, medicinal chemistry, and ADME groups) within the Drug Discovery Program, with other OICR Research Programs, and with academic and industry collaborators.
• Participate in team meetings, both internal and external.
• Present results to internal and external audiences, and contribute to funding requests, as well as manuscripts for peer-reviewed journals.
• Work effectively under pressure and tight timelines.
• Adhere to all OICR safety guidelines and policies, strongly advocates safety to others.

Qualifications:

• Ph.D. in Pharmacology, Biochemistry, or Cell Biology obtained within the last four (4) years with an excellent publication record.
• Strong knowledge in protein biochemistry with significant experience in enzymology, binding assays, and protein characterization.
• Experience working with E3 ligases, and/or protein-protein interaction studies.
• Experience in small molecule screening and/or working with targeted families of proteins.
• Great team player with excellent interpersonal and communication skills.
• Highly motivated self-starter who enjoys an element of ambiguity and is willing to adapt to a changing environment.

For more information about OICR, please visit the website at .

To learn more about working at OICR, visit our .

CLOSING DATE: Until Filled

OICR is committed to fostering a climate of equity, diversity, inclusion, and accessibility. This commitment is central to, and mutually supportive of, our research excellence mandate. We welcome and respect the diversity of all members of our community and we support an inclusive culture for all. We welcome all applicants, and encourage applications from racialized persons, Indigenous Peoples, women, persons with disabilities, LGBTQ2S persons, and others who may contribute to furthering a diversity of ideas within our community. OICR is committed to fair assessment of a candidate\xe2\x80\x99s abilities, and consideration for diversity of thought, method, and experience. Providing an accessible workplace and recruitment process is important to us, as described in our Accessibility Plan ( ). Should you require accommodation during any stage in the recruitment process, please complete the form at the bottom of page . Information received related to accommodation will be handled confidentially.

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.

Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .pdf or .doc file.

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