Job Description

Company Description

Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biotechnology company developing a diverse pipeline of novel, multifunctional biotherapeutics to improve the standard of care for difficult-to-treat diseases, including cancer, inflammation, and autoimmune disease. Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop antibody-based therapeutic candidates. We are a global company headquartered in Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, Singapore and Redwood City, CA.

Why Work With Us

Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.



This role can be located in any of our hubs in Vancouver BC, Bellevue WA, or Redwood City CA, and is hybrid with a minimum of 3 days per week onsite.

How You'll Contribute

The Associate Scientist will be representing the Clinical Bioanalysis function as part of the Clinical Pharmacology team and working closely with a multi-disciplinary drug development and translational team to support programs from late-stage discovery to early clinical development and all the way to post-market approval.

What You'll Do

Design bioanalytical methods to evaluate PK, and immunogenicity to support late stage preclinical and all stages of clinical development for Zymeworks portfolio of multispecific antibodies and ADCs. Oversee and manage bioanalytical method transfer, assay development and validation at contract research organizations (CROs). Design, oversee and manage critical reagent generation campaigns at CROs. Manage in-house and CRO critical reagent inventory and life cycle management. Ensure that bioanalytical work performed at CROs is in line with relevant regulatory guidance's and meets the scientific needs of the program. Collaborate with cross-functional team members to design assays and contribute to the overall strategy to develop multispecific antibodies and ADCs. Writes and reviews relevant sections of regulatory and scientific documentation including Clinical Study Protocols, IBs, SOPs, Statistical Analysis Plans and Clinical Study Reports. Reviewing/Authoring scientific publications, abstracts, posters Maintains a working knowledge of pharmacology, biology, therapeutics, drug metabolism, bioanalysis, and biopharmaceutics. Maintain a positive, results-orientated work environment, building partnerships and modeling teamwork, and communicating to the team in an open, balanced and objective manner. Summarizes and presents results to supervisor in a logical manner, verbally and in written reports or presentations. May present data to project team meetings. Other duties as assigned.

What You'll Bring

PhD or equivalent in Pharmacology/Biomedicine/Biochemistry or related scientific discipline with a minimum 1-3 years of relevant experience within a pharmaceutical industry, contract research, or clinical research. Hands-on experience with large molecule PK, and ADA bioanalytical method development and validation is a must. Experience managing bioanalytical work and reagent generation campaigns at CROs is highly desirable. Experience performing PK studies and data analysis (e.g. Winnonlin) in a drug development setting is an asset. Capable of anticipating and recognizing potential problems within project plans and effectively communicate alternatives. Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional team. Advanced spreadsheet skills are desirable. Strong scientific writing skills. Exceptional analytical and problem-solving capabilities. Effective interpersonal, written and verbal communication skills. Ability to manage multiple projects, prioritize work, and meet deadlines.

Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies.



The base salary range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position in the location for which the job is posted and does not include bonus, equity, or benefits. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate's location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).



Our total rewards package that includes:

Industry leading vacation and paid time off Exceptional medical, dental and vision benefits by country Zymelife health and wellness benefits Matching RRSP / 401K / Pension program Employee Share Purchase Program Employee Equity Program Paid time off to volunteer in your community


This role is not eligible for relocation or immigration support.



All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.

NOTE TO AGENCIES:

Zymeworks values our relationships with our recruiting partners. We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.

The pay range for this role is:

86,250 - 132,250 CAD per year(CA)